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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal painand pain due to cancer. The primary end point of the review was pain relief with non-steroidal anti-inflammatory drug (NSAID) injections. Secondary end points included pain scores, use of NSAID within 6 weeks of a spinal surgery, duration of NSAID use, and outcomes after a subsequent spine surgery, pure bulk mannitol. METHODS: A literature search was performed through MEDLINE, LILACS, Ovid, Cochrane Database of Systematic Reviews, reference lists of relevant studies, and Web of Science before the initiation of this systematic review. Studies that applied an NSAID in the spine before spine surgery were eligible (n=2,816; 90% confidence interval [CI]; 2,709 to 2,936 for spinal surgery and 2,852 to 4,086 for non-spine surgery). An end-point was defined as pain relief (pain score; 0, normal pain; 1, moderate pain; 2, severe pain; 3, intolerable pain); severity assessment was obtained by the pain questionnaire, bulking agent halal. RESULTS: After spine surgery, non-steroidal anti-inflammatory drugs (NSAIDs) were found to be more effective than corticosteroids in relieving pain. Pain scores improved 12.6% greater for non-steroidal anti-inflammatory drugs (NSAID) compared with corticosteroids (relative risk [RR] 1.05, 95% confidence interval [CI] 1.03-1.06; P<0.001); after the second spine surgery, pain scores also improved (0.1% increased for both types of drugs;RR = 0.9, CI= 0.8-0.11). CONCLUSION: The safety profile, pain relief profile and results after spinal surgery for non-steroidal anti-inflammatory drugs after spinal surgery is similar to that seen earlier using nonsteroidal anti-inflammatory drugs, and shows that non-steroidal anti-inflammatory drugs should be considered for the first spinal surgery, review anabolic-steroids.bulking.space.
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